Cristiano Ronaldo became the first player to score 50 goals in Serie A, La Liga and the Premier League as his double against Lazio put Juventus on the brink of the Serie A title.
Juve are eight points clear of Inter Milan and need four points to clinch a ninth consecutive title.
Ronaldo opened the scoring with a penalty and tapped in a second from Paulo Dybala's pass.
Ciro Immobile scored a penalty to pull one back for fourth-placed Lazio.
Ronaldo and Immobile are joint top scorers in Serie A with 30 goals each. Portugal captain Ronaldo is bidding to become the first Juve player to win the Serie A golden boot since Alessandro del Piero in 2007-08.
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