Ole Gunnar Solskjaer's side totally dominated the contest at the Amex Stadium and extended their unbeaten run to 15 games to move up to fifth in the Premier League, two points adrift of Chelsea.
Teenager Mason Greenwood bamboozled Seagulls defender Lewis Dunk with quick footwork and drilled in an accurate opener for the visitors.
United were ruthless in the final third as midfield playmaker Bruno Fernandes, who was highly impressive once again, netted via a deflection, then volleyed in to finish a swift counter-attack.
Brighton did pose some threat in the second half but David de Gea made a flying save to deny Aaron Connolly as Graham Potter's side remain in 15th place, six points above the relegation zone.
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